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The synthesis of new metallophthalocyanine-oligonucleotide conjugates is reported. These conjugates can cause sequence-specific photosensitized or catalytic oxidation of DNA by molecular oxygen.
The research was made possible in part by grants from CRDF (U.S.A.) (No. REC-008) and from Russian Foundation for Basic Research (99-04-48077 and 00-15-97784). The work was supported by Russian Government Program “Gene-directed biologically active compounds”.
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