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Nucleosides, Nucleotides & Nucleic Acids Volume 20, 2001 - Issue 4-7
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Original Articles

SYNTHESIS AND BASE PAIRING PROPERTIES OF 9-DEAZAPURINE N7-NUCLEOSIDES IN OLIGONUCLEOTIDE DUPLEXES AND TRIPLEXES

P. Leonard Institut für Chemie, Universität Osnabrück, Laboratorium für Organische und Bioorganische Chemie, Germany
,
T. Wiglenda Institut für Chemie, Universität Osnabrück, Laboratorium für Organische und Bioorganische Chemie, Germany
&
F. Seela Institut für Chemie, Universität Osnabrück, Laboratorium für Organische und Bioorganische Chemie, Germany
Pages 1279-1282 | Published online: 07 Feb 2007
 
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Abstract

The 9-deazaguanine N7-2′-deoxyribofuranoside (3) as well as the bromo and iodo derivatives 4a,b were synthesized and incorporated in oligonculeotide duplexes and triplexes. Their base pairing properties were investigated and compared with those of the parent purine N7-2′-deoxyribofuanosides.

Acknowledgments

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