LARGE-SCALE MANUFACTURING OF ALL FOUR 2′-DEOXYNUCLEOSIDES VIA NOVEL STRATEGIES INCLUDING A CHEMO-ENZYMATIC PROCESS

Hironori Komatsu Chemical Synthesis Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba, 297-0017, Japan

Hirokazu Awano Chemical Synthesis Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba, 297-0017, Japan

Hiroharu Tanikawa Chemical Synthesis Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba, 297-0017, Japan

Kiyoshi Itou Life Science Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba, 297-0017, Japan

Ichirou Ikeda Life Science Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba, 297-0017, Japan

Abstract

A chemical synthesis of 2-deoxyribose-1-phosphate 2 and its enzymatic conversion into purine 2′-deoxynucleosides (dNus) are shown. Besides the chemo-enzymatic process for purine dNus, a modified process for practical dC preparation is also established. Consequently, a series of practical manufacturing processes of all four dNus have been realized via novel strategies.

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LARGE-SCALE MANUFACTURING OF ALL FOUR 2′-DEOXYNUCLEOSIDES VIA NOVEL STRATEGIES INCLUDING A CHEMO-ENZYMATIC PROCESS

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LARGE-SCALE MANUFACTURING OF ALL FOUR 2′-DEOXYNUCLEOSIDES VIA NOVEL STRATEGIES INCLUDING A CHEMO-ENZYMATIC PROCESS

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