DEALKYLATION OF PHOSPHONATE ESTERS WITH CHLOROTRIMETHYLSILANE

A. J. Gutierrez Department of Chemical Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California, 94404, U.S.A.

E. J. Prisbe Department of Chemical Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California, 94404, U.S.A.

J. C. Rohloff Department of Chemical Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California, 94404, U.S.A.

Abstract

Chlorotrimethylsilane completely dealkylates phosphonate esters at elevated temperature in a sealed reaction vessel. These conditions are tolerated by a variety of functional groups and lead to high conversions of dimethyl, diethyl and diisopropyl phosphonates to their corresponding phosphonic acids.

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DEALKYLATION OF PHOSPHONATE ESTERS WITH CHLOROTRIMETHYLSILANE

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DEALKYLATION OF PHOSPHONATE ESTERS WITH CHLOROTRIMETHYLSILANE

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