ANTISENSE OLIGONUCLEOTIDE ISIS 2922 TARGETS IE-EXPRESSION AND PREVENTS HCMV-IE-INDUCED SUPPRESSION OF TSP-1 AND TSP-2 EXPRESSION

S. Margraf J. W. Goethe University Hospital, Inst. f. Med. Virology, Paul Ehrlich-Str. 40, Frankfurt am Main, D - 60596, Germany

M. Bittoova J. W. Goethe University Hospital, Inst. f. Med. Virology, Paul Ehrlich-Str. 40, Frankfurt am Main, D - 60596, Germany

J-U. Vogel J. W. Goethe University Hospital, Inst. f. Med. Virology, Paul Ehrlich-Str. 40, Frankfurt am Main, D - 60596, Germany

R. Kotchekov J. W. Goethe University Hospital, Inst. f. Med. Virology, Paul Ehrlich-Str. 40, Frankfurt am Main, D - 60596, Germany

H. W. Doerr J. W. Goethe University Hospital, Inst. f. Med. Virology, Paul Ehrlich-Str. 40, Frankfurt am Main, D - 60596, Germany

J. Cinatl Jr. J. W. Goethe University Hospital, Inst. f. Med. Virology, Paul Ehrlich-Str. 40, Frankfurt am Main, D - 60596, Germany

Abstract

ISIS 2922, but not ganciclovir (GCV), inhibits HCMV immediate early protein (IE) expression in different infected cell lines and prevents down-modulation of extracellular matrix proteins thrombospondin-1 and -2 induced by IE proteins. While action of ISIS 2922 is mainly due to specific inhibition of IE 2 mRNA, there is also evidence for unspecific effects in terms of inhibition of virus adhesion and penetration.

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ANTISENSE OLIGONUCLEOTIDE ISIS 2922 TARGETS IE-EXPRESSION AND PREVENTS HCMV-IE-INDUCED SUPPRESSION OF TSP-1 AND TSP-2 EXPRESSION

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ANTISENSE OLIGONUCLEOTIDE ISIS 2922 TARGETS IE-EXPRESSION AND PREVENTS HCMV-IE-INDUCED SUPPRESSION OF TSP-1 AND TSP-2 EXPRESSION

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