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Abstract
An electrochemical DNA sensing technique was developed by using ferrocenyl naphthalene diimide coupled with a probe DNA-immobilized electrode. This technique enabled detection of target DNA quickly and with high sensitivity. Applicability of this technique for single nucleotide polymorphisms (SNPs) analysis was demonstrated by successful analysis of a DNA mismatch on the cancer repression gene p53 with high precision.
ACKNOWLEDGMENTS
This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan and from the Japan Society for the Promotion of Science. The authors are also grateful for a financial support from the New Energy and Industrial Technology Development Organization (NEDO) of Japan.