SYNTHESIS AND ANTI-HIV ACTIVITY OF NEW MODIFIED 1,2,3-TRIAZOLE ACYCLONUCLEOSIDES

Abstract

The synthesis of 1,2,3-triazole acyclonucleosides 7a-h via 1,3-dipolar cycloaddition of N-9/N-1-propargylpurine/pyrimidine 2a-h with azido-pseudo-sugar 4 is described and none of them had anti-HIV activity.

ACKNOWLEDGMENTS

This work was supported by CNRS (France), DFG (Germany) and CNR (Morocco) and the inter-universities cooperation (AI 1141/96). We thank Prof. J. L. Abbud Mas of the C.S.I.C., Madrid, Spain, and Prof. W. Pfleiderer, University of Konstanz, Konstanz, Germany for their help and their interest in this work. We thank Kristien Etven for excellent technical assistance.