INCORPORATION OF 8-HISTAMINYL-DEOXYADENOSINE [8-(2-(4-IMIDAZOLYL)ETHYLAMINO)-2′-DEOXYRIBOADENOSINE] INTO OLIGODEOXYRIBONUCLEOTIDES BY SOLID PHASE PHOSPHORAMIDITE COUPLING

Leonard Lermer Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B.C., V6T-1Z1, Canada

John Hobbs NAPS (Nucleic Acid and Peptide Sequencing) Unit, University of British Columbia, 6174 University Blvd., Vancouver, B.C., V6T-1Z1, Canada

David M. Perrin Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B.C., V6T-1Z1, CanadaCorrespondence[email protected]

ABSTRACT

The 3′phosphoramidite of 8-histaminyl deoxyadenosine has been prepared and successfully incorporated into a short oligodeoxyribonucleotide. The synthetic methodology leading to this preparation is given and the implications for developing new DNAzymes as well as probing unusual nucleic acid structures are discussed.

ACKNOWLEDGMENT

This work was supported by UBC Start-up funds.

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INCORPORATION OF 8-HISTAMINYL-DEOXYADENOSINE [8-(2-(4-IMIDAZOLYL)ETHYLAMINO)-2′-DEOXYRIBOADENOSINE] INTO OLIGODEOXYRIBONUCLEOTIDES BY SOLID PHASE PHOSPHORAMIDITE COUPLING

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INCORPORATION OF 8-HISTAMINYL-DEOXYADENOSINE [8-(2-(4-IMIDAZOLYL)ETHYLAMINO)-2′-DEOXYRIBOADENOSINE] INTO OLIGODEOXYRIBONUCLEOTIDES BY SOLID PHASE PHOSPHORAMIDITE COUPLING

ABSTRACT

ACKNOWLEDGMENT

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