Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities

Ulf B. Christensen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark; Unest A/S, Lille Tornbjerg Vej 24 B, DK‐5220, Odense SØ, Denmark

Michael Wamberg Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, DenmarkCorrespondence[email protected]

Farag A. G. El‐Essawy Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark

Abd El‐Hamid Ismail Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark

Christina B. Nielsen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark

Vyacheslav V. Filichev Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark

Carsten H. Jessen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark

Michael Petersen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark

Erik B. Pedersen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark

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Abstract

Six new examples of intercalating nucleic acids were synthesized in order to evaluate the dependence of the length of the linker between oligo and intercalator on the thermal stability of their corresponding duplexes and triplexes.

^†In honour and celebration of the 70th birthday of Professor Leroy B. Townsend.

^††A research center funded by The National Danish Research Foundation for studies on nucleic acid chemical biology.

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Notes

^†In honour and celebration of the 70th birthday of Professor Leroy B. Townsend.

^††A research center funded by The National Danish Research Foundation for studies on nucleic acid chemical biology.

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Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities

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Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities

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