Synthesis of 4‐Formyl‐4‐imidazolin‐2‐one Nucleosides, Isomers of Uridine and 2′‐Deoxyuridine

Abstract

The syntheses of the ribo‐ and deoxyribonucleoside derivatives of 4‐formyl‐4‐imidazolin‐2‐one, isosteric isomers of uridine and 2′‐deoxyuridine, respectively, were carried out by ring contraction of the corresponding 5‐bromouracil nucleosides, followed by conversion of the carboxyl side‐chain of the products to the respective carboxaldehyde derivatives.

^†In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.

Keywords:

• Uridine
• 2′‐Deoxyuridine
• Nucleosides

Acknowledgment

This work was supported in part by research grant R01 AI27251 awarded to T.I.K. by the National Institutes of Health, USPHS.

Notes

^†In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.