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Abstract
The frequency of APC, RASSF1A, RARβ, CDH1 and CDH13 gene promoter methylation in samples of DNA isolated from breast and lung patient plasma was studied in order to develop the noninvasive tumor‐specific DNA detection method. Methylation of at least one of genes was detected in extracellular DNA from most of the cancer blood specimens. The results obtained indicate that promoter hypermethylation of a number of marker genes represents a promising serum marker for early breast and lung cancer detection.
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Acknowledgments
The present work was supported by grants of Russian Foundation of Basic Research 03‐04‐48647, INTAS 99‐00630, and grant support from Science‐ Technical Programms of RF Ministry of Education UR.07.01.008, from Natural Sciences Fundamental Research Department of RF Ministry of Education E02‐6.0‐39.
