Abstract
Molecular interactions of RNA cleaving compounds–conjugates of 1,4‐diazabicyclo[2.2.2.]‐octane substituted at the bridge position with tetradecamethylene fragment and imidazole were investigated using light scattering and small angle x‐ray scattering methods. The compounds are known to efficiently cleave RNA and one source of the activity could result from micellar catalysis. It was found that the compounds indeed are capable of forming complex aggregates in solution. However, maximal efficacy of RNA cleavage by the conjugates is observed at concentrations well below the concentration required for micelle formation.
Acknowledgments
This work was supported by grants CRDF REC‐NO‐008‐X1, SS‐1384.2003.4, RFBR 02‐04‐48664 and The Welcome Trust 063630.