Molecular Design of Artificial Ribonucleases Using Electrostatic Interaction

Abstract

A number of small organic ribonucleases have been synthesized with rigid polycationic structures containing an aromatic framework with two residues of bis‐quaternary salts of 1,4‐diazabicyclo[2.2.2]octane (DABCO) bearing various substituents. The compounds carrying positively charged groups connected via rigid linker are expected to bend the sugar‐phosphate backbone and can stimulate the intramolecular phosphoester transfer reaction.

Keywords:

• Artificial ribonuclease
• RNA cleavage
• 1,4‐diazabicyclo[2.2.2]octane

Acknowledgments

This work was supported by RFBR (02‐04‐48664‐a), BRHE (Rec‐008), Wellcome Trust (CRIG 063630) and Russian Science Support Foundation.