Release of Nucleic Acids by Eukaryotic Cells in Tissue Culture

Evgeniy S. Morozkin Institute of Bioorganic Chemistry Siberian Division, Russian Academy of Sciences, 8, Lavrentier Ave., Novosibirsk‐90, 630090, Russia

Pavel P. Laktionov Institute of Bioorganic Chemistry Siberian Division, Russian Academy of Sciences, 8, Lavrentier Ave., Novosibirsk‐90, 630090, RussiaCorrespondence[email protected]

Elena Y. Rykova Institute of Bioorganic Chemistry Siberian Division, Russian Academy of Sciences, 8, Lavrentier Ave., Novosibirsk‐90, 630090, Russia

Olga E. Bryzgunova Institute of Bioorganic Chemistry Siberian Division, Russian Academy of Sciences, 8, Lavrentier Ave., Novosibirsk‐90, 630090, Russia

Valentin V. Vlassov Institute of Bioorganic Chemistry Siberian Division, Russian Academy of Sciences, 8, Lavrentier Ave., Novosibirsk‐90, 630090, Russia

Abstract

Extracellular nucleic acids in cultures of A431 and HeLa cells were investigated. The data obtained demonstrate the presence of high weight DNA and RNA in the extracellular medium. Temporal changes of extracellular nucleic acids levels in growth medium were investigated.

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Acknowledgments

The present work was supported by the grants of Russian Foundation of Bacic Research 03‐04‐48647, INTAS 99‐00630, and grant support from Science–Technical Programs of RF Ministry of Education UR.07.01.008, from Natural Sciences Fundamental Research Department of RF Ministry of Education E02‐6.0‐39.

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