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Abstract
Joining the thrombin-binding aptamer 5′-d(GGTTGGTGTGGTTGG) and the minihairpin 5′-d(GCGAAGC) leads to new DNA nanoparticles, which are different from rod-like helical double-stranded DNA. Covalent interstrand cross-links in DNA duplexes generated by bifunctional alkadiyne chains were used to build-up the DNA networks.