SYNTHETIC STUDY OF 3′-α-FLUORO-2′,3′-DIDEOXYGUANOSINE

Abstract

A synthetic method was established for 3′-α-fluoro-2′,3′-dideoxyguanosine 1 from guanosine 2 in 27% overall yield and 6 steps. A byproduct 6a of fluorination was identified by NMR studies, its presence strongly supporting our supposition that the fluorination itself proceeded via a bromonium cation.

Keywords:

• 3′-α-fluoro-2′
• 3′-dideoxyguanosine