EXPRESSION OF THE MT₁ MELATONIN RECEPTOR SUBTYPE IN HUMAN CORONARY ARTERIES

Cem Ekmekcioglu Department of Physiology, University of Vienna, Medical School, Schwarzspanierstrasse 17, Vienna, A-1090, Austria

Petra Haslmayer Department of Pathophysiology, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria

Catherina Philipp Department of Physiology, University of Vienna, Medical School, Schwarzspanierstrasse 17, Vienna, A-1090, Austria

Mohammad R. Mehrabi Department of Cardiology, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria

Helmut D. Glogar Department of Cardiology, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria

Michael Grimm Department of Cardio-Thoracic Surgery, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria

Valentin J. Leibetseder Department of Physiology, University of Vienna, Medical School, Schwarzspanierstrasse 17, Vienna, A-1090, Austria

Theresia Thalhammer Department of Pathophysiology, University of Vienna, General Hospital (AKH), Währinger Gürtel 18–20, Vienna, 1090, Austria

Wolfgang Marktl Department of Physiology, University of Vienna, Medical School, Schwarzspanierstrasse 17, Vienna, A-1090, Austria

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Abstract

Previous experimental data suggest a possible influence of melatonin on the circulatory system of animals after binding to G-protein coupled melatonin receptors. The present study sought to investigate whether the melatonin receptor, mt₁, is expressed in human coronary arteries derived from healthy heart donors (n = 8). Expression of the mt₁-receptor was studied in sections of isolated coronary arteries by a reverse transcriptase-polymerase chain reaction (RT-PCR) and Western immunoblot technique. The analyses of the results from both methods indicated the presence of the mt₁-receptor in all of the subjects. Referring to these data we assume that melatonin regulates physiological processes in human coronary arteries after receptor binding.

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EXPRESSION OF THE MT₁ MELATONIN RECEPTOR SUBTYPE IN HUMAN CORONARY ARTERIES

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EXPRESSION OF THE MT₁ MELATONIN RECEPTOR SUBTYPE IN HUMAN CORONARY ARTERIES