A SYNTHESIS OF THE PYRANO[3,2-b]PYRIDINE RING SYSTEM UNDER MILD CONDITIONS

Abstract

A route to the relatively rare pyrano[3,2-b]pyridin-4-one template (1) is described starting from 3-hydroxypyridine. This synthesis allows for varying the substituents at the 2- and 3-positions of the bicycle. A diisopropylsilyloxy moiety was employed to direct lithiation of a pyridine intermediate to the less favored 2-position.

Acknowledgments