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Abstract
The synthesis of fluoroheterocyclic ketene aminals was investigated. Fluorobenzyl ketene dithioacetals 1c reacted with nitric acid in the presence of concentrated sulfuric acid to give compound 2c. 1 reacted with diamines to afford 3–4. C-fluorobenzylation of 3–4 give the corresponding 5–8.
ACKNOWLEDGMENTS
This work was supported by NIH grant R01 CA 64983 from the National Cancer Institute and the Innovative Biotechnology Research Fund of the Pennsylvania State University.