SYNTHESIS OF (S)-(+)-2-AMINO-6-(AMINOOXY)-HEXANOIC ACID

Maciej Adamczyk Department of Chemistry (9NM, Bldg AP20-2), Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL, 60064-6016, U.S.A.Correspondence[email protected]

Rajarathnam E. Reddy Department of Chemistry (9NM, Bldg AP20-2), Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL, 60064-6016, U.S.A.

Abstract

(S)-(+)-2-Amino-6-(aminooxy)hexanoic acid (AAHA, 3), a non-proteinogenic amino acid, and its derivative, (S)-(−)-6-{[(tert-butoxycarbonyl)amino]oxy}-2-{[(9H-fluoren-9-ylmethoxy)-carbonyl]amino}hexanoic acid (4), were synthesized from (S)-(−)-6-amino-2-{[(benzyloxy)carbonyl] amino}hexanoic acid (5) in good overall yield.

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SYNTHESIS OF (S)-(+)-2-AMINO-6-(AMINOOXY)-HEXANOIC ACID

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SYNTHESIS OF (S)-(+)-2-AMINO-6-(AMINOOXY)-HEXANOIC ACID

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