SYNTHESIS OF 2-METHYLCHROMONE-8-ACETIC ACIDS AND 2-METHYLCHROMONE-8-CARBOXYLIC ACIDS

Abstract

2-Hydroxy-3-allylacetophenones on Claisen condensation with EtOAc/Na gave intermediate diketone, followed by cyclization in AcOH/HCl gave 8-allyl/-1-propenylchromones, which on ozonolysis gave 8-acetaldehydes or 8-carboxaldehydes. The above aldehydes on oxidation with KMnO₄ furnished corresponding 8-acetic acids and 8-carboxylic acids.

ACKNOWLEDGMENTS

One of the authors (SGJ) thanks CSIR, New Delhi, for awarding SRF and the Director, IICT, for provding spectra. The authors also thank UGC, New Delhi, for financial assistance in the form of Special Assistance Programme (SAP).