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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 10
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Original Articles

HIGHLY EFFICIENT SYNTHESIS OF 2-AMINO-3-PYRIDINECARBOXALDEHYDE

Pages 1573-1579 | Received 03 Aug 2000, Published online: 02 Aug 2010
 

Abstract

2-Amino-3-pyridinecarboxaldehyde is synthesized in a highly efficient process via ortho-lithiation of 2-(pivaloylamino)pyridine and reaction with DMF, followed by acid hydrolysis. Major impurities were identified and were cleanly eliminated through careful choice of base and solvent.

ACKNOWLEDGMENTS

We thank Dr. P.G. Dormer and Ms. L.M. DiMichele for their NMR support and Dr. Z. Guan for high-resolution mass spectra.

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