Abstract
2-Amino-3-pyridinecarboxaldehyde is synthesized in a highly efficient process via ortho-lithiation of 2-(pivaloylamino)pyridine and reaction with DMF, followed by acid hydrolysis. Major impurities were identified and were cleanly eliminated through careful choice of base and solvent.
ACKNOWLEDGMENTS
We thank Dr. P.G. Dormer and Ms. L.M. DiMichele for their NMR support and Dr. Z. Guan for high-resolution mass spectra.