SYNTHESIS OF SUBSTITUTED-Δ²-1,2,4-TRIAZOLIN-5-ONES AND S-SUBSTITUTED ISOTHIOBIUREAS FROM 1-ARYL/ALKYL-6-PHENYL-2-THIOBIUREAS

Abstract

Reaction of 1-aryl/ alkyl-6-phenyl-2-thiobiureas 1 with BnCl and BuI in neutral medium at reflux temperature resulted in the formation of the S-alkylated isothiobiureas 2 and 1,2,4-triazolin-5-one derivatives 3. A convenient route to 2 is also reported.

ACKNOWLEDGMENTS

The authors acknowledge the instrumental services rendered by the National Single Crystal Diffractometer Facility (established by DST) at the School of Chemistry, University of Hyderabad, for crystal structure, National Chemical Laboratory, Pune, for elemental analysis, and Central Drug Research Institute, Lucknow, for EIMS spectra.