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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 12
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Original Articles

IMPROVED SYNTHESIS OF 3-SPIRO INDOLINES IN DRY MEDIA UNDER MICROWAVE IRRADIATION

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Pages 1879-1892 | Received 23 Aug 2000, Published online: 16 Aug 2006
 

Abstract

An efficient, one-pot synthesis of novel spiro [indole-dipyrrolopyridines] (8) was achieved under microwave irradiation by the interaction of spiro [indole-dipyrrolopyrans] (3) with ammonium acetate (7) in the presence of acetic acid. Spiro [indole-dipyrrolopyrans] (3) were synthesized “in situ” by the reaction of indole-2,3-diones (1) and 2-pyrrolidone (2) in 1:2 molar ratio by microwave induced techniques for the first time. Comparative studies have been made between (a) microwave irradiation of (i) neat reaction of reactants in the absence of any solvent or catalyst (ii) reaction in presence of o-dichlorobenzene and (b) classical heating.

ACKNOWLEDGMENT

Financial Assistance from U.G.C., Bhopal is gratefully acknowledged.

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