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Abstract
5-p-[N-(2-Pyrrolidinone)]phenyl-10,15,20-triphenylporphyrin 3, a novel potential photodynamic therapy drug, was synthesized in high yield in two steps starting from aminotetraphenylporphyrin 1 by first introduction of a chlorobutyramido group, then intramolecular cyclization under base conditions.
ACKNOWLEDGMENTS
This work was supported by The National Natural Science Foundation of China (29572071, 39830090), Ministry of Science and Technology of China (1995-043) and Beijing National Laboratory of Structural Chemistry of Stable and Unstable Species. We are also grateful to Dr. Elisabeth Cheu (University of British Columbia) for help on the preparation of this manuscript.