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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 13
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Original Articles

A MILD, ONE-POT METHOD FOR THE CONVERSION OF CARBOXYLIC ACIDS INTO THE CORRESPONDING WEINREB AMIDES

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Pages 2011-2019 | Received 05 Jul 2000, Published online: 09 Nov 2006
 

Abstract

Reaction of various carboxylic acids with N,O-dimethylhydroxylamine under modified Mukaiyama amide coupling conditions affords the corresponding Weinerb amides in generally high yield.

ACKNOWLEDGMENTS

We thank the Institute of Advanced Studies for financial support including the provision of a post-Doctoral Fellowship (to JS) and AMRAD (Melbourne) for a post-Doctoral Research Award (to JS).

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