A SHORT PROCEDURE FOR SYNTHESIS OF 4-ETHYNYL-2,2,6,6-TETRAMETHYL-3,4-DEHYDRO-PIPERIDINE-1-OXYL NITROXIDE

Peter M. Gannett School of Pharmacy, West Virginia University, Basic Pharmaceutical Sciences, P.O. Box 9530, Morgantown, West Virginia, 26506-9530, U.S.A.

Eva Darian School of Pharmacy, West Virginia University, Basic Pharmaceutical Sciences, P.O. Box 9530, Morgantown, West Virginia, 26506-9530, U.S.A.

Jeannine H. Powell School of Pharmacy, West Virginia University, Basic Pharmaceutical Sciences, P.O. Box 9530, Morgantown, West Virginia, 26506-9530, U.S.A.

Edward M. Johnson School of Pharmacy, West Virginia University, Basic Pharmaceutical Sciences, P.O. Box 9530, Morgantown, West Virginia, 26506-9530, U.S.A.

Abstract

The spin-probe labeling technique has been applied to DNA and offers the possibility of studying antisense agents in cells. Simpler syntheses of spin-probes for incorporation into DNA would facilitate this. Here, we describe the synthesis of a new spin probe that requires half the number of steps of related 5 ring nitroxide.

ACKNOWLEDGMENTS

We thank the NIH for their financial support of this work (15GM57630-01).

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A SHORT PROCEDURE FOR SYNTHESIS OF 4-ETHYNYL-2,2,6,6-TETRAMETHYL-3,4-DEHYDRO-PIPERIDINE-1-OXYL NITROXIDE

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A SHORT PROCEDURE FOR SYNTHESIS OF 4-ETHYNYL-2,2,6,6-TETRAMETHYL-3,4-DEHYDRO-PIPERIDINE-1-OXYL NITROXIDE

Abstract

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