CATALYTIC ASYMMETRIC OXIDATION OF SULFIDES MEDIATED BY A SERIES OF NOVEL OXAZOLINES-TITANIUM COMPLEXES

Abstract

A series of chiral oxazoline-titanium complexes were found to be efficient catalysts for the enantioselective oxidation of sulfides. The reactivity and enantioselectivity were strongly influenced by the structure of the oxazolines. When (4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2′-hydroxy-3′-tert-butylphenyl) oxazoline was used as ligand, the sulfoxide was obtained in 96%e.e.

ACKNOWLEDGMENTS

We thank the National Natural Science Foundation of China (No. 29832020) and The Hong Kong Polytechnic University ASD Fund for financial support of the study.