POTENTIAL INTERMEDIATES FOR DITERPENOID QUINONES: CRYPTOTANSHINONE, TANSHINONE IIA, AND MILTIRONE

Abstract

The transformation of the cyclic ethers (1) and (11) to dimethyl tetraol (8) and tetrahydrophenanthrene (14) respectively is described. These compounds proved to be a useful building block for the synthesis of angularly fused diterpenoid quinones.

ACKNOWLEDGMENT

The authors gratefully acknowledge the partial economic support from CONICIT to accomplish this work, which constitutes a part of the work of Project SI-98000387. We are grateful to Professor R.L. Danheiser, MIT, Cambridge for providing a copy of NMR spectra of tetraol.