Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 16
Submit an article Journal homepage
97
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

A GENERAL PROCEDURE FOR THE SYNTHESIS OF ACYLGUANIDINES DERIVED FROM ALIPHATIC AND AROMATIC AMINES

Seetharamaiyer Padmanabhan Cambridge NeuroScience Inc., One Kendall Square, Bldg. 700, Cambridge, MA, 02139, U.S.A.
,
Ruth C. Lavin Cambridge NeuroScience Inc., One Kendall Square, Bldg. 700, Cambridge, MA, 02139, U.S.A.
,
Paresh M. Thakkar Genetics Institute, 85 Bolton Street, Cambridge, MA, 02140, U.S.A.
&
Graham J. Durant Cambridge NeuroScience Inc., One Kendall Square, Bldg. 700, Cambridge, MA, 02139, U.S.A.
Pages 2491-2497 | Received 10 Nov 2000, Published online: 09 Nov 2006
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Condensation of aliphatic and aromatic amines with 1-aroyl- S-methylisothiourea in the presence of triethylamine affords acylguanidines in moderate to good yields. An improved procedure for the generation of 1-aroyl-S-methylisothiourea derivatives is described.

ACKNOWLEDGMENT

The authors wish to thank M. E. Perlman, Lu Zhang, Aine Cullinan and Deke Moore for the HPLC purity determination of the products.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.