Abstract
Condensation of aliphatic and aromatic amines with 1-aroyl- S-methylisothiourea in the presence of triethylamine affords acylguanidines in moderate to good yields. An improved procedure for the generation of 1-aroyl-S-methylisothiourea derivatives is described.
ACKNOWLEDGMENT
The authors wish to thank M. E. Perlman, Lu Zhang, Aine Cullinan and Deke Moore for the HPLC purity determination of the products.