ENAMINONES IN ORGANIC SYNTHESIS: A NOVEL SYNTHESIS OF 1,3,5-TRISUBSTITUTED BENZENE DERIVATIVES AND OF 2-SUBSTITUTED-5-AROYLPYRIDINES

ABSTRACT

Enaminones undergo self-condensation on reflux in acidic media yielding 1,3,5-trisubstituted benzene in very high yields. Reaction of enaminones 1a,b with ethyl propiolate affords 5-aroyl-1,3-benzene dicarboxylate derivatives.

ACKNOWLEDGMENT

We are grateful to Alexander Von Humboldt stiftung for granting a Stependium to Prof. M. H. Elnagdi. The discussion of Prof. E. Fanghanel at University of Halle is highly appreciated. Some ¹H NMR and ¹³C NMR spectra were carried out at University of Halle.