A CONVENIENT PREPARATION OF 1,2,3,4,5,6,7,8-OCTAHYDRO-NAPHTHALENE SKELETON. SYNTHESIS OF (±)-ISOCARIDIENE

ABSTRACT

Synthesis of isocaridiene, an isomeric compound of natural sesquiterpene caridiene, is described starting from myrcene. Dehydration of tertiary alcohol leading exclusively to isocaridiene was in agreement with the semiempirical and ab initio quantum mechanical calculations.

ACKNOWLEDGMENTS

This work was performed with financial support of FAPESP and MC thanks CAPES-PICD for fellowship. We also thank Dr. L.H.B. Baptistella for helpful discussions.