1,3-DIPOLAR CYCLOADDITION REACTIONS OF 3′,5′-BIS-O-SILYL THYMIDINES. SYNTHESIS OF NOVEL AZABICYCLIC COMPOUNDS

G. Negrón Area de Química Aplicada, Universidad Autónoma Metropolitana, Av. San Pablo No 180, México, D.F., C.P. 02200, MéxicoCorrespondence[email protected]

G. Calderón Area de Química Aplicada, Universidad Autónoma Metropolitana, Av. San Pablo No 180, México, D.F., C.P. 02200, México

F. Vázquez Area de Química Aplicada, Universidad Autónoma Metropolitana, Av. San Pablo No 180, México, D.F., C.P. 02200, México

L. Lomas Departamento de Química, Universidad Autónoma Metropolitana, Av. San Pablo No 180, México, D.F., C.P. 02200, México

J. Cárdenas Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., México

C. Márquez Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., México

R. Gaviño Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., México

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ABSTRACT

An efficient one step procedure for the preparation of (4.3.0) bicyclic N-methylpyrrolidine thymidine derivatives 4, using cycloaddition reaction of the highly reactive non-stabilized azomethine ylide [Y] with 3′,5′-Bis-O-silylthymidines 3.

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ACKNOWLEDGMENTS

The authors are indebted to Consejo Nacional de Ciencia y Tecnología (CONACyT) for partial financial support (Project No 33366-E). Messrs, A. Acosta and L. Velasco for their technical assistance.

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1,3-DIPOLAR CYCLOADDITION REACTIONS OF 3′,5′-BIS-O-SILYL THYMIDINES. SYNTHESIS OF NOVEL AZABICYCLIC COMPOUNDS

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1,3-DIPOLAR CYCLOADDITION REACTIONS OF 3′,5′-BIS-O-SILYL THYMIDINES. SYNTHESIS OF NOVEL AZABICYCLIC COMPOUNDS

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