PREPARATION OF 8-ALKYL 7-(2-IMIDAZOLINYLAMINO)QUINOLINES VIA PALLADIUM MEDIATED ALKYLATIONS

Nick Nikolaides Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, OH, 45040, U.S.A.Correspondence[email protected]

Sophie E. Bogdan Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, OH, 45040, U.S.A.

James S. Szalma Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, OH, 45040, U.S.A.

ABSTRACT

A convenient preparation of 8-alkyl substituted 7-(2-imidazolinylamino)quinolines from the corresponding 8-trifluoromethanesulfonates, utilizing palladium cross-coupling reactions is described.

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PREPARATION OF 8-ALKYL 7-(2-IMIDAZOLINYLAMINO)QUINOLINES VIA PALLADIUM MEDIATED ALKYLATIONS

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PREPARATION OF 8-ALKYL 7-(2-IMIDAZOLINYLAMINO)QUINOLINES VIA PALLADIUM MEDIATED ALKYLATIONS

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