A CONVENIENT SYNTHESIS OF 2,3-DISUBSTITUTED DERIVATIVES OF 4H-PYRIMIDO[2,1-b]-BENZOTHIAZOLE-4-ONE

ABSTRACT

4H-Pyrimido[2,1-b ]benzothiazole-2-thiomethyl-3-cyano-4-one (3) has been prepared by the reaction of 2-amino benzothiazole (1) with ethyl-2-cyano-3,3-bismethyl thio acrylate (2) in the presence of dimethyl formamide and anhydrous potassium carbonate. Susceptibility of compound (3), towards condensation with different reagents like aryl amines, heteryl amines, phenols and compounds containing active methylene groups has been investigated.

ACKNOWLEDGMENT

Authors are grateful to Dr. B. S. Dhengle, Principal, Yeshwant Mahavidyalaya, Nanded, for providing laboratory facilities and Director, Indian Institute of Chemical Technology, Hyderabad, for providing Spectra.