SYNTHESIS OF A NEW CHIRAL o-HYDROXYARYLDIAZAPHOSPHONO- DIAMIDE AS LIGAND CATALYSTS FOR ASYMMETRIC SILYLCYANATION OF AROMATIC ALDEHYDES

Zhuo-Hong Yang Wuhan Insititute of Science and Technology, Wuhan, 430073, P.R. China

Zheng-Hong Zhou State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. China

Li-Xin Wang State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. China

Kang-Ying Li State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. China

Qi-Lin Zhou State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. China

Chu-Chi Tang State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. ChinaCorrespondence[email protected]

ABSTRACT

A new chiral o-hydroxyaryldiazaphosphonodiamide 1 was synthesized from (−)-α-methylbenzylamine, it was found to be efficient ligand for the Ti(O-iPr)₄ catalyzed asymmetric trimethylsilylcyanation of aldehydes. Corresponding aromatic cyanohydrins were obtained in good chemical yield and enantiomeric excesses (e.e.s) up to 90%.

ACKNOWLEDGMENT

We are grateful to the National Natural Science Foundation of China (No. 29872016 and 29725204) for the financial support.

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SYNTHESIS OF A NEW CHIRAL o-HYDROXYARYLDIAZAPHOSPHONO- DIAMIDE AS LIGAND CATALYSTS FOR ASYMMETRIC SILYLCYANATION OF AROMATIC ALDEHYDES

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SYNTHESIS OF A NEW CHIRAL o-HYDROXYARYLDIAZAPHOSPHONO- DIAMIDE AS LIGAND CATALYSTS FOR ASYMMETRIC SILYLCYANATION OF AROMATIC ALDEHYDES

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ACKNOWLEDGMENT

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