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Intramolecular Friedel–Crafts alkylation of N-benzyl-N-(1-cyclopropylethyl)acetamide to 3,4-dialkyl substituted tetrahydroisoquinoline by reaction of the acetamide with an excess of PPA is described. The conformational study of intermediates by high resolution NMR analysis is also reported.
Financial support from Colciencias (grants No. 1115-05-353-96 and 1102-05-110-97) is gratefully acknowledged.
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