Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 32, 2002 - Issue 19
193
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

A NOVEL AND EFFICIENT SYNTHESIS OF 4-PHENYL-2-CHLOROPYRIMIDINES FROM ACETOPHENONE CYANOIMINES

, &
Pages 3011-3018 | Received 14 Sep 2001, Published online: 16 Aug 2006
 

ABSTRACT

A versatile and efficient 2 step synthesis of 4-phenyl-2-chloropyrimidines is described. The reaction proceeds by treatment of acetophenone cyanoimines under Vilsmeier–Haack conditions to give the target compounds in moderate yields.

ACKNOWLEDGMENTS

The authors would like to thank Drs. Brian Buckwalter and William Wood for their assistance and discussions in the preparation of this manuscript, Mr. Ron Lopata for mass spectral analysis and interpretation and Ms. Terri Verderese for typing the manuscript.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.