MULTIGRAM-SCALE STEREOSELECTIVE SYNTHESIS OF MESO-1,3-BUTADIENE BISEPOXIDE

ABSTRACT

meso-1,3-Butadiene bisepoxide, a potential building block for natural product synthesis and of interest as a toxic metabolite of butadiene, was synthesized in multi-gram scale in two steps from meso-erythritol in good overall yield.

Keywords:

• Mesobutadiene bisepoxide
• Synthesis
• Metabolite
• Butadiene

ACKNOWLEDGMENTS

This work was supported in part by agreement 99-5 from the Health Effects Institute and Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA.