A SIMPLE AND EFFICIENT METHOD FOR REDUCTIVE ACYLATION OF AZIDES USING ALUMINIUM IODIDE AND ACETIC ANHYDRIDE

ABSTRACT

A combination of aluminium iodide and acetic anhydride effectively converts a variety of azides to their corresponding acetamides in good to excellent yields without perturbing many active functionalities such as ether, ester, nitro etc.

Keywords:

• Reductive acylation
• Azide
• Acetamide
• Aluminum iodide
• Acetic anhydride

ACKNOWLEDGMENT

Author is grateful to Vice Chancellor, Dibrugarh University for providing laboratory facilities for this work. Author is also grateful Dr. N. C. Barua, Scientist, RRL, Jorhat, (India) for helpful discussion.