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ABSTRACT
A convenient and effective synthesis of enantiomerically pure macrocyclic dioxopolyamine 3 and its derivatives 4–9 is presented. Macrocyle 3, derived from l-proline, was prepared in high overall yield and easily modified. 8 and 9 were prepared by modified Mannich reaction in good yields.
ACKNOWLEDGMENT
This work was supported by Hubei Province Science Foundation, and by a grant from The Education Ministry of China for the visiting scholar to the Key Laboratory of Bioorganic Chemistry and Molecular Engineering.