SELECTIVE PREPARATION OF α,α-DICHLOROKETONES WITH COPPER(II) CHLORIDE

ABSTRACT

Aryl and enolizable alkyl ketones react with copper(II) chloride in dimethylformamide to produce the corresponding α,α-dichloroketone in high yields. Remarkable qualities of the process are high selectivity towards these substrates, undetected polychlorinated by-products, easy work-up, commercially available reagents and HCl as the only waste stream.

Keywords:

• Dichloroketones
• Dichlorination
• Copper(II) chloride

ACKNOWLEDGMENTS

C.P. thanks CAPES and FAPERGS for financial support. J.A.N. thanks CNPq for the award of a scholarship.