A NEW SYNTHETIC ACCESS TO 2-TRIHALOGENOMETHYL- 3,4-DIHYDROFURO[2,3-d]- PYRIMIDIN-4-ONES

ABSTRACT

2-Amino-5-alkoxycarbonylfurans 1a–c react with 1-chloro-2,2,2-trihalogenoethyliden-O-methylurethanes 2a,b at room temperature to give N-(2-furyl)-N′-methoxycarbonyl-trihalogenoacetamidines 3a–f which cyclize into 2-trihalogenomethyl-3,4-dihydrofuro[2,3-d]pyrimidin-4-ones 4a–f on boiling in toluene.

Keywords:

• 2-Amino-5-alkoxycarbonylfurans
• 1-Chloro-2,2,2-trihalogenoethyliden-O-methylurethanes
• N-(2-Furyl)-N-methoxycarbonyltrihalogenoacetamidines
• 2-Trihalogenomethyl-3,4-di-hy-drofuro[2,3-d]pyrimidin-4-ones

Acknowledgments