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Abstract
Convenient synthesis of a series of 4-ethoxycarbonyl-5-arylisoxazolidines (6a–c) is described, via N-tetrahydropyran-2-yl protected intermediates (5a–c). Regioselectivity of this reaction is confirmed by high-field NMR experiments, and is shown to agree with theoretical predictions
Acknowledgments
The authors would like to gratefully acknowledge the financial support of the Ontario Neurotrauma Foundation (RSJ) and the Canadian Institutes of Health Research (JS).