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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 1
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Original Articles

A Facile Synthesis of Phenylacetic Acids via Willgerodt-Kindler Reaction Under PTC Condition

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Pages 59-63 | Received 22 Oct 2001, Published online: 20 Aug 2006
 

Abstract

Phenylacetic acids are efficiently synthesized from acetophenones via thiomorpholides under Phase Transfer Catalytic (PTC) condition. The reaction proceeds efficiently by using triethyl benzyl ammonium chloride (TEBA) as PTC and the reaction time decreased dramatically upto 1/5th (24–5) to afford pure products in good to excellent yield.

Acknowledgments

The authors wish to thank Dr. K. V. Raghavan, Director of IICT and Dr. B. M. Choudary, Head of the Division, for their encouragement.

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