Mild and Efficient Synthesis of Phthalazine-1,4-diones Using PTSA in the Solid State

Abstract

A rapid and efficient method for the synthesis of 1,8-naphthyridine-3-carbonyl phthalazine-1,4-diones by the condensation of 1,8-naphthyridine-3-carboxylic acid hydrazides with phthalic anhydride using p-toluenesulphonic acid (PTSA) as a catalyst under solid state conditions has been described. The reaction proceeds efficiently at room temperature in excellent yields and in a state of high purity.

Acknowledgments

We are grateful to the Directors, IICT, Hyderabad, and CDRI, Lucknow, for providing spectral data. DSC thanks UGC, New Delhi for research fellowship.