New Synthesis of Optically Active α-Arylpropanoic Acid: The Asymmetric Hydrogenation of Atropic Acid over Cinchona-Modified Pd/Fe₂O₃ Catalysts

H.-Zh. Ma College of Chemistry and Materials Science, Shaanxi Normal University, Xi'An, P.R., China

B. Wang College of Chemistry and Materials Science, Shaanxi Normal University, Xi'An, P.R., China; College of Chemistry and Materials Science, Shaanxi Normal University, 710062, Shaanxi Province, Xi'An, P.R., ChinaCorrespondence[email protected]

Q.-Zh. Shi College of Chemistry and Materials Science, Shaanxi Normal University, Xi'An, P.R., China

Abstract

The first satisfactory application of the heterogeneous cinchona-modified Pd/Fe₂O₃ catalyst system in the synthesis of optically active α-arylpropanoic acid, namely, the highly enantioselective (up to 87% ee) hydrogenation of atropic acid to S-(+)-naproxen is described.

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New Synthesis of Optically Active α-Arylpropanoic Acid: The Asymmetric Hydrogenation of Atropic Acid over Cinchona-Modified Pd/Fe₂O₃ Catalysts

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New Synthesis of Optically Active α-Arylpropanoic Acid: The Asymmetric Hydrogenation of Atropic Acid over Cinchona-Modified Pd/Fe2O3 Catalysts

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New Synthesis of Optically Active α-Arylpropanoic Acid: The Asymmetric Hydrogenation of Atropic Acid over Cinchona-Modified Pd/Fe₂O₃ Catalysts