A General Uncatalyzed Method for the Synthesis of O-Silylated Oximes

Margarita Ortiz-Marciales Department of Chemistry, University of Puerto Rico, CUH Station, Humacao, PR, USA; Department of Chemistry, University of Puerto Rico, CUH Station, Humacao, PR, 00791, USACorrespondence[email protected]

Melvin De Jesús Department of Chemistry, University of Puerto Rico, CUH Station, Humacao, PR, USA

Dyliana Figueroa Department of Chemistry, University of Puerto Rico, CUH Station, Humacao, PR, USA

Jesús Hernández Department of Chemistry, University of Puerto Rico, CUH Station, Humacao, PR, USA

Leslie Vázquez Department of Chemistry, University of Puerto Rico, CUH Station, Humacao, PR, USA

Rafael Vega Department of Chemistry, University of Puerto Rico, CUH Station, Humacao, PR, USA

Eduardo M. Morales Department of Chemistry, University of Puerto Rico, CUH Station, Humacao, PR, USA

José A. López Department of Chemistry, University of Puerto Rico, CUH Station, Humacao, PR, USA

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Abstract

Aldoximes and ketoximes were smoothly and efficiently O-silylated at room temperature with diverse chlorosilanes such as TMSCl, TBSCl, or TIPSCl in dichloromethane or THF, using imidazole as a base to trap the generated hydrochloric acid.

Acknowledgments

This work was supported by the National Institute of Health, MBRS Program Grant (GM 08216) and AREA Grant (GM 59829). ONR and NSF-AMP undergraduate's support is also gratefully acknowledged. We thank Mr. José Martínez (University of Puerto Rico, Río Piedras) for obtaining the NMR spectra.

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A General Uncatalyzed Method for the Synthesis of O-Silylated Oximes

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A General Uncatalyzed Method for the Synthesis of O-Silylated Oximes

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