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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 3
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Original Articles

A New Protocol for Selective Deprotection of N-tert-Butoxycarbonyl Protective Group (t-Boc) with Sn(OTf)2

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Pages 445-450 | Received 22 Feb 2002, Published online: 17 Aug 2006
 

Abstract

A simple and efficient method for the selective removal of N-Boc group by employing tin(II) trifluoromethanesulfonate [Sn(OTf)2] in CH2Cl2 or solvent-free conditions was developed. The scope of this procedure is explored for the deprotection of a variety of amines, including amino acid derivatives.

#IICT Communication No. 4372.

Acknowledgment

One of the authors (K.K.K) thanks CSIR, New Delhi for financial support in the form of research fellowship.

Notes

#IICT Communication No. 4372.

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