Synthesis of Substituted Indolo[1,2-a]quinoxalines

Abstract

1-(2-Nitrophenyl)indole-2-carboxylates 5, obtained by the N-arylation of indole-2-carboxylates 4, on catalytic reductive cyclization afford indolo[1,2-a]quinoxalino-6(5H)-ones 6. These compounds on reduction with LAH in ether/THF yielded indolo[1,2-a]quinoxalines 7.

Keywords:

• N-Arylation
• LAH
• Reduction
• Ethyl indole-2-carboxylates
• Indolo[1,2-a]quinoxalines

Acknowledgments

We thank the Director, and Dr. G. A. Naganagowda of SIF, Indian Institute of Science, Bangalore, India, for providing NMR facility to carry out the 2D-NMR studies.